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Mevastatin
| Product Name | Mevastatin |
| Price: | $28 / 20mg |
| Catalog No.: | CN08664 |
| CAS No.: | 73573-88-3 |
| Molecular Formula: | C23H34O5 |
| Molecular Weight: | 390.51 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | From Penicillium Citrinum. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC[C@@H](C(=O)O[C@H]1CCC=C2[C@H]1[C@@H](CC[C@@H]1C[C@@H](O)CC(=O)O1)[C@H](C=C2)C)C |
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| Description | Mevastatin (Compactin; ML236B) inhibits HMGCR (HMG-CoA reductase) (Ki for acid form is 1 nM) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. IC50 value: 1 nM (Ki)Target: HMGCRMevastatin induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Mevastatin suppresses TNF-induced NF-κB activation (IC50 = ~17 uM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 555.0±50.0 °C at 760 mmHg |
| Flash Point | 186.5±23.6 °C |
| Exact Mass | 390.240631 |
| PSA | 72.83000 |
| LogP | 3.57 |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
| Storage condition | 2-8°C |